Forces that influence the evolution of codon bias

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Forces that influence the evolution of codon bias.

The frequencies of alternative synonymous codons vary both among species and among genes from the same genome. These patterns have been inferred to reflect the action of natural selection. Here we evaluate this in bacteria. While intragenomic variation in many species is consistent with selection favouring translationally optimal codons, much of the variation among species appears to be due to ...

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Background: There is a 3-fold redundancy in the Genetic Code; most amino acids are encoded by more than one codon. These synonymous codons are not used equally; there is a Codon Usage Bias (CUB). This article will provide novel information about the origin and evolution of this bias. Results: Codon Usage Bias (CUB, defined here as deviation from equal usage of synonymous codons) was studied in ...

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ژورنال

عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences

سال: 2010

ISSN: 0962-8436,1471-2970

DOI: 10.1098/rstb.2009.0305